Because IMITREX Injection may increase blood pressure, it should not be given to patients with uncontrolled hypertension. Do you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40? Who should not take IMITREX? IMITREX Injection is contraindicated in patients with hypersensitivity to sumatriptan or any of its components. perindopril discount at cvs perindopril
Teratogenicity: Term fetuses from Dutch Stride rabbits treated during organogenesis with oral sumatriptan exhibited an increased incidence of cervicothoracic vascular and skeletal abnormalities. The functional significance of these abnormalities is not known. Imitrex Tablets. Such reactions can be life threatening or fatal. Cartridge Pack out of the Carrying Case. Your blood pressure will need to be checked often. valtrex order visa
These are not all the possible side effects of IMITREX. In a trial of 14 healthy females, pretreatment with an MAO-A inhibitor decreased the clearance of subcutaneous sumatriptan, resulting in a 2-fold increase in the area under the sumatriptan plasma concentration-time curve AUC corresponding to a 40% increase in elimination half-life. An autoinjection system is available for self-administration. These drugs are similar to the in this medication and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose to prevent or usually at dosages of 81-325 milligrams a day you should continue taking the aspirin unless your doctor instructs you otherwise.
Relief is defined as the reduction of moderate or severe pain to no or mild pain after dosing without use of rescue medication. Hold the Pen by the ridges at the top. IMITREX Injection 1 hour after the initial injection. Choose and Prepare the Injection Site. aricept kaufen shop
Drug-Associated Cerebrovascular Events and Fatalities: Cerebral hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported in patients treated with oral or subcutaneous sumatriptan, and some have resulted in fatalities. The relationship of sumatriptan to these events is uncertain. In a number of cases, it appears possible that the cerebrovascular events were primary, sumatriptan having been administered in the incorrect belief the symptoms experienced were a consequence of migraine when they were not. As with other acute migraine therapies, before treating headaches in patients not previously diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, care should be taken to exclude other potentially serious neurological conditions. Store Imitrex spray between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex spray in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex spray out of the reach of children and away from pets. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. Following subcutaneous administration of sumatriptan, pain, redness, stinging, induration, swelling, contusion, subcutaneous bleeding, and, on rare occasions, lipoatrophy depression in the skin or lipohypertrophy enlargement or thickening of tissue have been reported. PREGNANCY and BREAST-FEEDING: It is not known if Imitrex tablets can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imitrex tablets while you are pregnant. Imitrex tablets are found in breast milk. If you are or will be breast-feeding while you use Imitrex tablets, check with your doctor. Discuss any possible risks to your baby. You should give an injection as soon as the symptoms of your headache start, but it may be given at any time during a migraine or cluster headache attack. Table 1 lists adverse reactions that occurred in 2 US placebo-controlled clinical trials in migraine patients Studies 2 and 3 following either a single 6-mg dose of Imitrex Injection or placebo. Overuse of Imitrex tablets can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor. This should not be taken if you have certain medical conditions.
Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody diarrhea; burning or aching in your feet or toes; burning, numbness, or tingling; constipation; diarrhea; fainting; feeling of heaviness or tightness in your leg muscles; fever; hearing problems; leg cramps; seizures; severe or persistent headache, dizziness, nausea, or vomiting; severe stomach pain; very cold or blue fingers or toes; vision changes or loss of vision; weight loss; wheezing. How should I use sumatriptan? Heart attack and other heart problems. The Pen is now ready to use. You tend to get them at the same time each year, such as the spring or fall. Because of their seasonal nature, people often mistake for or business stress. The following wording is contained in a separate leaflet provided for patients. No gross overdoses in clinical practice have been reported. Triptans narrow constrict vessels in the and relieve swelling. Triptans have other properties that may help treat symptoms. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. There may be new information. Product Information. Imitrex sumatriptan. bicalutamide
Special Populations: Renal Impairment: The effect of renal impairment on the pharmacokinetics of sumatriptan has not been examined, but little clinical effect would be expected as sumatriptan is largely metabolized to an inactive substance. If any of these effects persist or worsen, tell your doctor or promptly. Mild or flushing may occur. These effects are usually temporary and may disappear as your body adjusts to this product. If any of these effects persist or worsen, contact your doctor or promptly. The use of Imitrex Tablets is contraindicated in patients with ischemic or vasospastic CAD. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of Imitrex Tablets. Some of these reactions occurred in patients without known CAD. Cluster headaches are more common in people who smoke or are heavy drinkers. During a cluster period, you'll be more sensitive to alcohol and nicotine -- just a bit of alcohol can trigger a headache. But drinking won't trigger one during headache-free periods. Medication overuse headache may present as migraine-like daily headaches, or as a marked increase in frequency of migraine attacks. Detoxification of patients, including withdrawal of the overused drugs, and treatment of withdrawal symptoms which often includes a transient worsening of headache may be necessary. The vascular 5-HT 1 receptor subtype to which sumatriptan binds selectively, and through which it presumably exerts its antimigrainous effect, has been shown to be present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of the isolated dura mater of humans. In these tissues, sumatriptan activates this receptor to cause vasoconstriction, an action in humans correlating with the relief of migraine and cluster headache. In the anesthetized dog, sumatriptan selectively reduces the carotid arterial blood flow with little or no effect on arterial blood pressure or total peripheral resistance. In the cat, sumatriptan selectively constricts the carotid arteriovenous anastomoses while having little effect on blood flow or resistance in cerebral or extracerebral tissues. If your migraine symptoms go away and then come back, or if you have a partial response to the first dose, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses. The half-life of elimination of sumatriptan is about 2 hours see and therefore monitoring of patients after overdose with IMITREX Injection should continue while symptoms or signs persist, and for at least 10 hours. IMITREX STATdose System NDC 0173-0478-00. You can take it as a pill or as a suppository if nausea or vomiting stops you from keeping anything down. Another form of ergotamine, called DHE 45 also treats them. You can get it as an injection or as a nasal spray. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Imitrex can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert. Neither of these adverse events was associated with a serious clinical outcome.
Remove the nozzle from your nostril. Keep your head level for 10 to 20 seconds while gently breathing in through your nose and out through your mouth. Do NOT breathe in deeply. Pen from accidentally firing until you are ready. To prevent upset, take this medication with food, milk, or an antacid. Do not break, crush, or chew the tablet. Renal Impairment: The effect of renal impairment on the pharmacokinetics of sumatriptan has not been examined. Imitrex may cause serious side effects. See “What is the most important information I should know about Imitrex? Take the new Cartridge Pack out of its box. Silberstein SD, et al. 2012. Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology, 7817: 1337-1345. generic artane buy pharmacy uk
Overdose symptoms may include tremors, skin redness, scabs or scaly skin where you injected the medicine, weakness, lack of coordination, breathing problems, blue-colored lips or fingernails, vision problems, seizure convulsions or loss of movement in any part of your body. What should I avoid while using Imitrex Statdose sumatriptan injection? Some sumatriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. You may experience pain or redness at the site of injection, but this usually lasts less than an hour. CAD prior to receiving Imitrex Tablets. If there is evidence of CAD or coronary artery vasospasm, Imitrex Tablets are contraindicated. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of Imitrex Tablets in a medically supervised setting and performing an electrocardiogram ECG immediately following administration of Imitrex Tablets. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of Imitrex Tablets. Discuss the risks and benefits with your doctor.
Remember, if you answered YES to any of the above questions, then discuss it with your doctor. Consult WARNINGS section for additional precautions. IMITREX Injection is indicated for 1 the acute treatment of migraine attacks with or without aura and 2 the acute treatment of cluster headache episodes. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. AUC and C max and a T max 40 minutes earlier compared to the healthy subjects. Do not use more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor. Product Information. SUMAtriptan Succinate SUMAtriptan. Nov. 7, 2003 -- The success or failure of treatment with the most commonly prescribed may depend on timing. Sumatriptan is excreted in human milk following subcutaneous administration. Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hours after treatment with Imitrex Injection. Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Some of these events occurred in patients who had no findings of CAD and appear to represent consequences of coronary artery vasospasm. IMITREX. Such reactions can be life threatening or fatal. Take Imitrex tablets by mouth with or without food. order suprax online pharmacy europe
Eye: Ischemic optic neuropathy, retinal artery occlusion, retinal vein thrombosis, loss of vision. IMITREX Injection in pregnant women. Prinzmetal variant all forms of myocardial infarction, and silent myocardial ischemia. Cerebrovascular syndromes include, but are not limited to, strokes of any type as well as transient ischemic attacks. Oral administration of sumatriptan to rats prior to and throughout gestation resulted in embryofetal toxicity decreased body weight, decreased ossification, increased incidence of skeletal abnormalities. Always consult a healthcare professional for medical advice. Most people will get daily headaches for 2 weeks to 3 months; in between these periods, they'll be pain-free for at least 2 weeks. About 2 of every 10 people with cluster headaches have less than 14 headache-free days per year. Reduce your stress. Being anxious can impair your memory. IMITREX Injection is intended to relieve your migraine or cluster headache, but not to prevent or reduce the number of attacks you experience. Use IMITREX Injection only to treat an actual migraine or cluster headache attack. This medication may interfere with certain laboratory tests including bleeding times, adrenal function tests possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Imitrex, AMERGE, and TREXIMET are registered trademarks of the GlaxoSmithKline group of companies. The other brands listed are trademarks of their respective owners and are not trademarks of GlaxoSmithKline. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products. Not applicable. See How to Use section. Product Information. Imitrex nasal spray sumatriptan.
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Pregnancy Category C: There are no adequate and well-controlled trials in pregnant women. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal. Imitrex Tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Imitrex is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. buy clavaseptin 120 mg clavaseptin
Attacks appear to be linked to the circadian rhythm, your body's 24-hour clock. They happen so regularly, generally at the same time each day, that they've been called "alarm clock headaches. Studies show caffeine makes pain relievers more effective and may help your body absorb other drugs, Calhoun says. But it has some drawbacks. Cerebral hemorrhage, subarachnoid hemorrhage, and stroke have occurred with 5-HT1 treatment; some have resulted in fatalities. One case of sumatriptan-induced cortical stroke has been reported in a patient with sagittal sinus thrombosis. In some cases, it appears possible that the cerebrovascular events were primary, and the 5-HT1 agonist administered in the belief that presenting symptoms were due to migraine when they were not. Patients with migraine may also be at an increased risk of certain cerebrovascular events such as stroke, hemorrhage, and transient ischemic attacks.
Side effects may go away after you take the medicine for a while. USP in water for injection, USP. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. IMITREX sumatriptan succinate Injection is a selective 5-hydroxytryptamine 1 receptor subtype agonist. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Do not take any MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. durko.info pantoprazole
Use before you start to use the IMITREX STATdose System. The Pen will only work when the Safety Catch is released. To release the Safety Catch, you must press the Pen firmly against your skin until the grey part of the barrel slides against the blue part and it cannot be pressed any further. The grey part of the barrel must stay in contact with the blue part while you inject your medicine. IMITREX is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. Refill Cartridge Packs are available. Our Imitrex Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.